NAD+ + MOTS-C + 5-Amino-1MQ Blend

This blend bundles three substances that aging research otherwise examines separately. NAD+ accounts for most of the mass; the other two components are added in equal shares. Each acts at a different point of energy metabolism:

• NAD+, the coenzyme without which sirtuins cannot work; responsible for sirtuin-mediated regulation of aging and for mitochondrial function. A 2016 paper explains why the level drops over the years: the molecule is increasingly destroyed.
• MOTS-c, a peptide whose blueprint sits not in the cell nucleus but in the genome of the mitochondria. Its first description in 2015 tied it to insulin sensitivity and energy balance; in 2021 it was characterized as a regulator, triggered by exercise, of the physical decline that comes with age and of muscle maintenance.
• 5-Amino-1MQ, a small molecule that inhibits the enzyme NNMT and thereby preserves SAM and nicotinamide in adipose tissue metabolism. In aging skeletal muscle such an inhibitor activated senescent muscle stem cells and improved regenerative capacity.

Preclinical data on the individual substances show overlapping effects on the formation of new mitochondria, on fat metabolism and on metabolic markers that shift with age; the idea of the combination derives from that. The caveat matters: as a combined injection the blend is young and far less well characterized than any single component. It is supplied as a lyophilisate that is dissolved before use; the composition is stated on the product page.

Three agents in one syringe mean three reaction patterns plus possible interactions for which hardly any data exist.

• NAD+ portion: Administered too fast, it can trigger intense flushing, pressure on the chest and nausea, the same pace-dependent pattern seen with pure NAD+.
• Broad intervention: All three components alter energy and lipid metabolism; the preclinical data on the single substances show shifted metabolic markers.
• Data gap of the blend: What is known about synergies comes from studies of the individual substances. The combined injection itself has barely been examined, let alone interactions in this form.
• Injection site: Redness or a feeling of pressure occur more frequently.
• Long term: Human studies on the blend do not exist.

This summary is no substitute for medical advice.

• Why NAD+ Declines during Aging: It's Destroyed - explains the age-related loss of NAD+ through increased breakdown.
• The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance - first description of MOTS-c with data on insulin sensitivity and metabolic homeostasis.
• Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle - shows how an NNMT inhibitor reactivates senescent muscle stem cells in old muscle.